WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Hedgehog signaling pathway       ID:04340
C=56; O=3; E=0.19; R=15.61; rawP=0.0010; adjP=0.0170
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101144 NA BMP7 bone morphogenetic protein 7 655 ENSG00000101144
2  ENSG00000114251 NA WNT5A wingless-type MMTV integration site family, member 5A 7474 ENSG00000114251
3  ENSG00000112210 NA RAB23 RAB23, member RAS oncogene family 51715 ENSG00000112210


Database:KEGG pathway       Name:Alanine, aspartate and glutamate metabolism       ID:00250
C=32; O=2; E=0.11; R=18.21; rawP=0.0054; adjP=0.0306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166123 NA GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 84706 ENSG00000166123
2  ENSG00000167701 NA GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2875 ENSG00000167701


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=4; E=0.69; R=5.80; rawP=0.0052; adjP=0.0306
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000090565 NA RAB11FIP3 RAB11 family interacting protein 3 (class II) 9727 ENSG00000090565
2  ENSG00000126803 NA HSPA2 heat shock 70kDa protein 2 3306 ENSG00000126803
3  ENSG00000139722 NA VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 79720 ENSG00000139722
4  ENSG00000147010 NA SH3KBP1 SH3-domain kinase binding protein 1 30011 ENSG00000147010


Database:KEGG pathway       Name:Sphingolipid metabolism       ID:00600
C=40; O=2; E=0.14; R=14.57; rawP=0.0084; adjP=0.0357
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163082 NA SGPP2 sphingosine-1-phosphate phosphatase 2 130367 ENSG00000163082
2  ENSG00000118276 NA B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 9331 ENSG00000118276


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=8; E=3.88; R=2.06; rawP=0.0417; adjP=0.0788
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166123 NA GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 84706 ENSG00000166123
2  ENSG00000159267 NA HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 3141 ENSG00000159267
3  ENSG00000167701 NA GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2875 ENSG00000167701
4  ENSG00000109107 NA ALDOC aldolase C, fructose-bisphosphate 230 ENSG00000109107
5  ENSG00000163344 NA PMVK phosphomevalonate kinase 10654 ENSG00000163344
6  ENSG00000156471 NA PTDSS1 phosphatidylserine synthase 1 9791 ENSG00000156471
7  ENSG00000103485 NA QPRT quinolinate phosphoribosyltransferase 23475 ENSG00000103485
8  ENSG00000118276 NA B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 9331 ENSG00000118276


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=3; E=0.73; R=4.10; rawP=0.0373; adjP=0.0788
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000137843 NA PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 56924 ENSG00000137843
2  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685
3  ENSG00000114279 NA FGF12 fibroblast growth factor 12 2257 ENSG00000114279


Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=2; E=0.29; R=6.94; rawP=0.0339; adjP=0.0788
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000049323 NA LTBP1 latent transforming growth factor beta binding protein 1 4052 ENSG00000049323
2  ENSG00000101144 NA BMP7 bone morphogenetic protein 7 655 ENSG00000101144


Database:KEGG pathway       Name:Fc gamma R-mediated phagocytosis       ID:04666
C=94; O=2; E=0.32; R=6.20; rawP=0.0416; adjP=0.0788
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000168907 NA PLA2G4F phospholipase A2, group IVF 255189 ENSG00000168907
2  ENSG00000241685 NA ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 10552 ENSG00000241685


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=2; E=0.27; R=7.38; rawP=0.0303; adjP=0.0788
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000115425 NA PECR peroxisomal trans-2-enoyl-CoA reductase 55825 ENSG00000115425
2  ENSG00000163344 NA PMVK phosphomevalonate kinase 10654 ENSG00000163344


Database:KEGG pathway       Name:Toxoplasmosis       ID:05145
C=132; O=2; E=0.45; R=4.42; rawP=0.0758; adjP=0.1030
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171791 NA BCL2 B-cell CLL/lymphoma 2 596 ENSG00000171791
2  ENSG00000126803 NA HSPA2 heat shock 70kDa protein 2 3306 ENSG00000126803




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).